Peter Adams Lab

Epigenetics of Cancer and Aging

Publication List

Journal Publications

  1. Adams PD, Parker PJ. TPA inducible activation of MAP kinase. FEBS Lett., 1991, 290:77-82.
  2. Adams, P.D., Parker, P.J. Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase. J. Biol. Chem., 1992, 267:13135-13137.
  3. Qin XQ, Livingston DM, Kaelin WG Jr, Adams PD. Deregulated E2F-1 expression leads to S phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 1994, 91:10918-10922.
  4. Adams PD, Sellers WR, Sharma SK, Wu AD, Nalin CM, Kaelin WG Jr. Identification of a Cyclin-Cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol., 1996, 16:6623-6633.
  5. Soucek T, Pusch O, Hengstschläger-Ottnad E, Adams PD, Hengstschläger M. Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position. Oncogene, 1997, 14:2251-2257.
  6. Kiley SC, Adams PD, Parker PJ. Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants. Cell Growth Differ., 1997, 8:221-230.
  7. Chen YN, Sharma SK, Ramsey TM, Jiang L, Martin MS, Baker K, Adams PD, Bair KW, Kaelin WG Jr. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc. Natl. Acad. Sci. USA, 1999, 96:4325-4329. PMCID: PMC16331.
  8. Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG Jr. Retinoblastoma protein contains a C terminal motif that targets it for phosphorylation by cyclin/cdk complexes. Mol. Cell. Biol., 1999, 19:1068-1080. PMCID: PMC116037.
  9. Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR, Gan J, DeCaprio JA, Adams PD, Kaelin WG Jr. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol. Cell. Biol., 2000, 20:8889-8902. PMCID: PMC86544.
  10. Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD, Wang J, Qin J, Chow LT, Harper JW. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev., 2000, 14:2298-2313. PMCID: PMC316935.
  11. Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin/cdk2 substrate whose expression blocks S-phase progression. Mol. Cell. Biol., 2001, 21:1854-1865. PMCID: PMC86753.
  12. Nelson DM, Ye X, Hall C, Santos H, Ma T, Kao GD, Yen TJ, Harper JW, Adams PD. Coupling of DNA synthesis and histone synthesis in S-phase independent of cyclin/cdk2 activity. Mol. Cell. Biol., 2002, 22:7459-7472. PMCID: PMC135676.
  13. Khare L, Astrinidis A, Senapedis W, Adams PD, Henske EP. Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells. J. Med. Genet., 2002, 39:676-680. PMCID: PMC1735223.
  14. Leng X, Noble M, Adams PD, Qin J, Harper JW. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol., 2002, 22:2242-2254. PMCID: PMC133692.
  15. Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD. Structure and function of the conserved core of histone deposition protein Asf1. Curr. Biol., 2003, 13:2148-2158.
  16. Adams PD, Cairns P. Clipped wings: Epigenetic inactivation of APC. Cancer Biol. Ther., 2004, 3:965-966. doi: 10.4161/cbt.2.5.588. PMID: 14614326.
  17. Ye X, Franco AA, Santos H, Nelson DM, Kaufman PD, Adams PD. Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Mol. Cell., 2003, 11:341-351. doi: 10.1016/s1097-2765(03)00037-6. PMID: 12620223.
  18. Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD. Formation of macroH2A-containing senescence associated heterochromatin foci (SAHF) and senescence driven by ASF1a and HIRA. Dev. Cell, 2005, 8:19-30. doi: 10.1016/j.devcel.2004.10.019. PMID: 15621527.
  19. Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD*, Marmorstein R*. Structure of a human ASF1a/HIRA complex and insights into specificity of histone chaperone complex assembly. Nature Struct. Mol. Biol., 2006, 13:921-929. *Corresponding authors. PMCID: PMC2933817.
  20. Nagamori I, Yomogida K, Adams PD, Sassone-Corsi P, Nojima H. Transcription Factors, cAMP-responsive Element Modulator (CREM) and Tisp40, Act in Concert in Postmeiotic Transcriptional Regulation. J Biol Chem., 2006, 281:15073-15081. doi: 10.1074/jbc.M602051200. PMID: 16595651.
  21. Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol. Cell., 2007, 27:183-196. PMCID: PMC2698096.
  22. Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, Adams PD. Definition of pRB- and p53-dependent and –independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol. Cell Biol., 2007, 27:2452-2465. PMCID: PMC1899904.
  23. Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell Biol., 2007, 27:2343-2358. PMCID: PMC1820509.
  24. Zhang R, Liu ST, Chen W, Bonner M, Pehrson J, Yen TJ, Adams PD. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol. Cell Biol., 2007, 27:949-962. PMCID: PMC1800672.
  25. Poleshko A, Palagin I, Zhang R, Boimel P, Castagna C, Adams PD, Skalka AM, Katz RA. Identification of Cellular Proteins that Maintain Retroviral Epigenetic Silencing: Evidence for an Antiviral Response. J. Virology, 2008, 82:2313-2323. PMCID: PMC2258957.
  26. Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol. Cell. Biol., 2009, 29:758-770. PMCID: PMC2630694.
  27. Ambagala AP, Bosma T, Ali MA, Poustovoitov M, Chen JJ, Gershon MD, Adams PD, Cohen JI. Varicella-Zoster Virus Immediate-Early 63 Protein Interacts with Human Anti-Silencing Function 1 Protein and Alters its Ability to Bind Histones H3.1 and H3.3. J. Virology, 2009, 83:200-209. PMCID: PMC2612320.
  28. Kennedy AL, McBryan T, Enders GH, Johnson FB, Zhang R, Adams PD. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. BMC Cell Division, 2010, 5:16. PMCID: PMC2904742.
  29. Poleshko A, Einarson MB, Shalginskikh N, Zhang R, Adams PD, Skalka AM, Katz RA. Identification of a functional network of human epigenetic silencing factors. J Biol Chem., 2010, 285:422-433. PMCID: PMC2804189.
  30. Ray-Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, Schultz DC, Pchelintsev NA, Adams PD, Jansen LE, Almouzni G. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell, 2011, 44:928-941. doi: 10.1016/j.molcel.2011.12.006. PMID: 22195966.
  31. Rai TS, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev NA, van Tuyn J, Marmorstein R, Schultz DC, Adams PD. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol. Cell. Biol., 2011, 31:4107-4118. PMCID: PMC3187368.
  32. Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell., 2011, 42:36-49. PMCID: PMC3145340.
  33. Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM. Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell, 2011, 10:292-304. PMCID: PMC3079313.
  34. Moyes LH, McEwan H, Radulescu S, Pawlikowski J, Lamm CG, Nixon C, Sansom OJ, Going JJ, Fullarton GM, Adams PD. Activation of Wnt Signalling promotes development of dysplasia in Barrett's Oesophagus. J. Pathology, 2012, 228:99-112. doi: 10.1002/path.4058. PMID: 22653845.
  35. Dekker P, Gunn D, McBryan T, Dirks RW, van Heemst D, Lim FL, Jochemsen AG, Verlaan-de Vries M, Nagel J, Adams PD, Tanke HJ, Westendorp RG, Maier AB. Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts. Mech. Aging and Dev.,2012, 133:498-507. doi: 10.1016/j.mad.2012.06.002. PMID: 22721680.
  36. Tang Y, Puri A, Ricketts MD, Rai TS, Hoffmann J, Hoi E, Adams PD, Schultz DC, Marmorstein R. Identification of an Ubinuclein 1 region required for stability of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry, 2012, 51:2366-2377. PMCID: PMC3320765.
  37. Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013, 504:296-300. doi: 10.1038/nature12865. PMID: 24305049.
  38. Cruickshanks HA, McBryan T, Nelson DM, Vanderkraats ND, Shah PP, van Tuyn J, Singh Rai T, Brock C, Donahue G, Dunican DS, Drotar ME, Meehan RR, Edwards JR, Berger SL, Adams PD. Senescent cells harbour features of the cancer epigenome. Nat Cell Biol. 2013, 15:1495-1506. PMCID: PMC4106249.
  39. Pawlikowski JS, McBryan T, van Tuyn J, Drotar ME, Hewitt RN, Maier AB, King A, Blyth K, Wu H, Adams PD. Wnt signaling potentiates nevogenesis. Proc. Natl. Acad. Sci USA., 2013, 110:16009-16014. PMCID: PMC3791768.
  40. Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD*, Berger SL* Lamin B1 Depletion in Senescent Cells Leads to Large-Scale Changes in the Chromatin Landscape. Genes and Development. 2013, 27:1787-1799. PMCID: PMC3759695. * Corresponding authors.
  41. Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. Lysosome-dependent processing of histones in senescent cells. J. Cell Biol., 2013, 202:129-143. PMCID: PMC3704985.
  42. Pchelintsev NA, McBryan T, Rai TS, van Tuyn J, Ray-Gallet D, Almouzni G, Adams PD. Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Reports, 2013, 3:1012-1019. PMCID: PMC3974909.
  43. Howard L, Mackenzie RM, Pchelintsev NA, McBryan T, McClure JD, McBride MW, Kane NM, Adams PD, Milligan G, Baker AH. Profiling of Transcriptional and Epigenetic Changes During Directed Endothelial Differentiation of Human Embryonic Stem Cells Identifies FOXA2 as a Marker of Early Mesoderm Commitment. Stem Cell Res Ther., 2013, 4:36. PMCID: PMC3706826.
  44. Sawicka M, Pawlikowski J, Wilson S, Ferdinando D, Wu H, Adams PD, Gunn DA, Parish W. The Specificity and Patterns of Staining in Human Cells and Tissues of p16INK4a Antibodies Demonstrate Variant Antigen Binding. PLoS One, 2013; 8:e53313. PMCID: PMC3540092.
  45. Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD. HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes Dev., 2014, 28:2712-2725. PMCID: PMC4265675.
  46. Soni S, Pchelintsev N, Adams PD, Bieker JJ. EKLF/KLF1 recruitment of HIRA is essential for -globin gene expression. Proc. Natl. Acad. Sci., 2014, 111:13337-13342. PMCID: PMC4169976.
  47. Lund K, Cole JJ, VanderKraats ND, McBryan T, Pchelintsev NA, Clark W, Copland M, Edwards JR, Adams PD. DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in Acute Myeloid Leukemia. Genome Biology, 2014, 15:406. PMCID: PMC4165364.
  48. Haas NB, Quirt I, Hotte S, McWhirter E, Polintan R, Litwin S, Adams PD, McBryan T, Wang L, Martin LP, vonMehren M, Alpaugh RK, Zweibel J, Oza A. Phase II trial of Vorinostat in advanced melanoma. Investigational New Drugs., 2014, 32:526-534. doi: 10.1007/s10637-014-0066-9. PMID: 24464266.
  49. Hofmann JW, McBryan T, Adams PD, Sedivy JM. The effects of aging on the expression of Wnt pathway genes in mouse tissues. Age, 2014, 36:9618. PMCID: PMC4082588.
  50. Nelson DM, McBryan T, Jeyapalan JC, Sedivy JM, Adams PD. A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging. Age (Dordr), 2014, 36:9637. PMCID: PMC4082585.
  51. Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL. Autophagy mediates degradation of nuclear lamina. Nature, 2015, 527:105-109. PMCID: PMC4824414.
  52. Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W, Hewitt RN, Sammons MA, Zhu J, Athineos D, Leach JD, Marchesi F, van Tuyn J, Tait SW, Brock C, Morton JP, Wu H, Berger SL, Blyth K, Adams PD. Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest. Cell Reports, 2015, 12:1483-1496. PMCID: PMC4562906.
  53. Pawlikowski JS, Brock C, Chen SC, Al-Olabi L, Nixon C, McGregor F, Paine S, Chanudet E, Lambie W, Holmes WM, Mullin JM, Richmond A, Wu H, Blyth K, King A, Kinsler VA, Adams PD. Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a novel murine model driven by activated NRAS and Wnt. J. Invest. Derm., 2015, 8:2093-2101. PMCID: PMC4539947.
  54. Ricketts MD, Frederick B, Hoff H, Tang Y, Schultz DC, Singh Rai T, Grazia Vizioli M, Adams PD, Marmorstein R. Ubinuclein-1 confers histone H3.3-specific binding specificity by the HIRA histone chaperone complex. Nat. Comms., 2015, 6:7711. PMCID: PMC4510971.
  55. Waaijer ME, Gunn DA, Adams PD, Pawlikowski JS, Griffiths CE, van Heemst D, Slagboom PE, Westendorp RG, Maier AB. P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2016, 71:1022-1028. PMCID: PMC4945882.
  56. Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression. Genome Biol., 2016, 17(1):158. PMCID: PMC4960804.
  57. Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Mitochondria are required for the pro-aging features of the senescent phenotype. EMBO J., 2016, 35:724-742. PMCID: PMC4818766.
  58. Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL. MLL1 epigenetically regulates expression of ATM and the senescence-associated secretory phenotype. Genes Dev., 2016, Feb 1;30(3):321-336. PMCID: PMC4743061.
  59. Maddocks, O.D.K., Labuschagne, C.F., Adams, P.D., Vousden, K.H. Serine metabolism supports the methionine cycle and DNA / RNA methylation through de novo ATP synthesis in cancer cells. Mol Cell, 2016, 61:210-221. PMCID: PMC4728077.
  60. Pchelintsev, N.A., Adams, P.D., Nelson, D.M., Critical parameters for efficient sonication and improved chromatin immunoprecipitation of high molecular weight proteins. PLoS One, 2016, 11(1):e0148023. PMCID: PMC4731078.
  61. Rai TS, Glass M, Cole JJ, Rather MI, Marsden M, Neilson M, Brock C, Humphreys IR, Everett RD, Adams PD. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research, 2017, 45:11673-11683. PMCID: PMC5691367.
  62. Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD*, Berger SL*. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature, 2017, 550:402-406. PMCID: PMC5850938. * Corresponding authors.
  63. Leung EY, McMahon JD, McLellan D, Syyed N, McCarthy CE, Nixon C, Orange C, Brock C, Hunter K., Adams PD. DNA damage marker γH2AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity. Histopathology, 2017, 71:522-528. doi: 10.1111/his.13260. PMID: 28543539.
  64. van Tuyn J, Jaber-Hijazi F, MacKenzie D, Cole JJ, Mann E, Pawlikowski JS, Rai TS, Nelson DM, McBryan T, Ivanov A, Blyth K, Wu H, Milling S, Adams PD. Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function. J. Invest. Derm., 2017, 137(10):2197-2207. PMCID: PMC5613751.
  65. Cole JJ, Robertson NA, Rather MI, Thomson JP, McBryan T, Sproul D, Wang T, Brock C, Clark W, Ideker T, Meehan RR, Miller RA, Brown-Borg HM, Adams PD. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biology, 2017, 18;58. PMCID: PMC5370462.
  66. Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Yu MK, Carter H, Brown-Borg HM, Adams PD, Ideker T. Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biology, 2017, 18:57. PMCID: PMC5371228.
  67. Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Cell Metab., 2018, 28:721-736.e6. PMCID: PMC6224545.
  68. Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD. AKT overactivation can suppress DNA repair via p70S6 Kinase-mediated MRE11 downregulation. Oncogene, 2018, 37:427-438. PMCID: PMC5799716.
  69. Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, Chapman J, Birch J, Ogrodnik M, Meves A, Pawlikowski JS, Jurk D, Adams PD, van Heemst D, Beekman M, Slagboom PE, Gunn DA, Passos JF.. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. EMBO J., 2019, 38:e101982. PMCID: PMC6885734.
  70. Costa TDF, Zhuang T, Lorent J, Turco E, Olofsson H, Masia-Balague M, Zhao M, Rabieifar P, Robertson N, Kuiper R, Sjölund J, Spiess M, Hernández-Varas P, Rabenhorst U, Roswall P, Ma R, Gong X, Hartman J, Pietras K, Adams PD, Defilippi P, Strömblad S. PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer. Nat Commun., 2019, 10:3589. PMCID: PMC6689091.
  71. Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, Kiourtis C, Müller M, Green AR, Adams PD, Acosta JC, Bird TG, Kirschner K, Neretti N, Chandra T. Notch Signaling Mediates Secondary Senescence. Cell Rep., 2019, 27:997-1007.e5. PMCID: PMC6486482.
  72. McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C. The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLOS Pathogens, 2019, 15:e1007667. PMCID: PMC6472835.
  73. Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Length-independent telomere damage drives cardiomyocyte senescence. EMBO J., 2019, 38(5). PMCID: PMC6396144.
  74. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell., 2019, 73:684-698. PMCID: PMC6688479.
  75. Guida MC, Birse RT, Dall'Agnese A, Toto PC, Diop SB, Mai A, Adams PD, Puri PL, Bodmer R. Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila. Nat Commun., 2019, 10:193. PMCID: PMC6331650.
  76. Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. SIRT1 is downregulated by autophagy in senescence and aging. Nat. Cell. Biol., 2020. 22:1170-1179. PMCID: PMC7805578.
  77. Wang T, Ma J, Hogan AN, Fong S, Licon K, Tsui B, Kreisberg JF, Adams PD, Carvunis AR, Bannasch DL, Ostrander EA, Ideker T. Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome. Cell Syst, 2020, 11:176-185.e6. PMCID: PMC7484147.
  78. Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, Perez-Garcia A, Kiourtis C, Dasgupta N, Lei X, Kruger PJ, Nixon C, Clark W, Jurk D, Bird TG, Passos JF, Berger SL, Dou Z, Adams PD. Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence. Genes Dev., 2020, 34:428-445. PMCID: PMC7050483.
  79. Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT. MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. Br J Cancer, 2020, 122:868-884. PMCID: PMC7078291.
  80. MacKenzie DJ, Robertson NA, Rather I, Reid C, Sendzikaite G, Cruickshanks H, McBryan T, Hodges A, Pritchard C, Blyth K, Adams PD. DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience, 2020, 23:100838. PMCID: PMC7000804.
  81. Chen C, Sun MA, Warzecha C, Bachu M, Dey A, Wu T, Adams PD, Macfarlan T, Love P, Ozato K. HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. Cell Rep., 2020, 30:2136-2149.e4. doi: 10.1016/j.celrep.2020.01.062. PubMed PMID: 32075733.
  82. Gerber JP, Russ J, Chandrasekar V, Offermann N, Lee HM, Spear S, Guzzi N, Maida S, Pattabiraman S, Zhang R, Kayvanjoo AH, Datta P, Kasturiarachchi J, Sposito T, Izotova N, Händler K, Adams PD, Marafioti T, Enver T, Wenzel J, Beyer M, Mass E, Bellodi C, Schultze JL, Capasso M, Nimmo R, Salomoni P. Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation. Nat Cell Biol., 2021, 23:1224-1239. PMCID: PMC8683376.
  83. Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. Blood, 2021, 137:3403-3415. PMCID: PMC8212510.
  84. Puthanmadhom Narayanan S, O'Brien D, Sharma M, Miller K, Adams P, Passos JF, Eirin A, Ordog T, Bharucha AE. Duodenal mucosal mitochondrial gene expression is associated with delayed gastric emptying in diabetic gastroenteropathy. JCI Insight, 2021, 6:e143596. PMCID: PMC7934845.
  85. Latif, A-L., Newcombe, A., Li, S., Gilroy, K., Robertson, N., Lei, X., Stewart, H., Cole, J., Terradas, M.T., Rishi, L., McGarry, L., McKeeve, C., Reid, C., Clark, W., Campos, J., Kirschner, K., Davis, A., Lopez, J., Sakamaki, J-i., Morton, J., Ryan, K.M., Tait, S., Abraham, S., Holyoake, T., Higgins, B., Huang, X., Blyth, K., Copland, M., Chevassut, T., Keeshan, K., Adams, P.D. BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 2021, 12:241. PMCID: PMC7801601.
  86. Onorati A, Havas AP, Lin B, Rajagopal J, Sen P, Adams PD, Dou Z. Upregulation of PD-L1 in Senescence and Aging. Molecular and Cellular Biology, 2022, 42:e0017122. PMCID: PMC9583718.
  87. Hao X, Shiromoto Y, Sakurai M, Towers M, Zhang Q, Wu S, Havas A, Wang L, Berger S, Adams PD, Tian B, Nishikura K, Kossenkov AV, Liu P, Zhang R. ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels. Nat Cell Biol., 2022, 24:1202-1210. PMCID: PMC9757154.
  88. Spiliopoulou P, Spear S, Mirza H, Garner I, McGarry L, Grundland-Freile F, Cheng Z, Ennis DP, Iyer N, McNamara S, Natoli M, Mason S, Blyth K, Adams PD, Roxburgh P, Fuchter MJ, Brown B, McNeish IA. Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma. Molecular Cancer Therapeutics, 2022, 21:522-534. PMCID: PMC9377747.
  89. Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM. PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion. Cell Rep., 2023, 42:112436. doi: 10.1016/j.celrep.2023.112436. PMID: 37115668.
  90. Sen P, Donahue G, Li C, Egervari G, Yang N, Lan Y, Robertson N, Shah PP, Kerkhoven E, Schultz DC, Adams PD, Berger SL. Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging. Nat Aging., 2023, 3:402-417. PMCID: PMC10165726.
  91. Missinato MA, Murphy S, Lynott M, Yu MS, Kervadec A, Chang YL, Kannan S, Loreti M, Lee C, Amatya P, Tanaka H, Huang CT, Puri PL, Kwon C, Adams PD, Qian L, Sacco A, Andersen P, Colas AR. Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells. Nat Commun., 2023, 14:1709. PMCID: PMC10043290.
  92. Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R. Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Aging Cell, 2023, 22:e13742. PMCID: PMC9835578.
  93. Novak ER, Deshpande A, Finlay D, Mason JR, Deshpande AJ, Adams PD, Li S. Detection of TP53 Mutation in Acute Myeloid Leukemia by RT-PCR-Based Sanger Sequencing. Methods Mol Biol., 2023, 2594:87-95. doi: 10.1007/978-1-0716-2815-7_7. PMID: 36264490.
  94. Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Erratum in: Nature. 2024 Jan 2; PMCID: PMC10584674.
  95. Miller, KN, Li, B, Pierce-Hoffman, HR, Lei, X, Havas, AP, Patel, S, Macip, CC, Victorelli, SG, Woo, S-H, Lagnado, AB, Liu, T, Dasgupta, N, Lyu, J, Altman, Y, Porritt, RA, Garcia, G, Mogler, C, Dou, Z, Chen, C, Passos, JF, Adams, PD (2023). A mitochondria-regulated p53-CCF circuit integrates genome integrity with inflammation. BioRxiv 2023.11.20.567963; doi: https://doi.org/10.1101/2023.11.20.567963
  96. Wang L, Donahue G, Zhang C, Havas A, Lei X, Xu C, Wang W, Vahedi G, Adams PD, Berger SL. Dynamic enhancer interactome promotes senescence and aging. BioRxiv. 2023 May. doi: https://doi.org/10.1101/2023.05.22.541769.
  97. Barbosa K, Deshpande A, Perales M, Xiang P, Murad R, Pramod AB, Minkina A, Robertson N, Schischlik F, Lei X, Sun Y, Brown A, Amend D, Jeremias I, Doench JG, Humphries RK, Ruppin E, Shendure J, Mali P, Adams PD, Deshpande AJ. Transcriptional control of leukemogenesis by the chromatin reader SGF29. Blood. 2024 Feb 22;143(8):697-712. doi: 10.1182/blood.2023021234; PMCID: PMC10900139.
  98. Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R. TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation. Nat Aging. 2024 Feb;4(2):185-197. doi: 10.1038/s43587-023-00564-1. Epub 2024 Jan 24; PMCID: PMC11210448.
  99. Alvarez-Kuglen M, Ninomiya K, Qin H, Rodriguez D, Fiengo L, Farhy C, Hsu WM, Kirk B, Havas A, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV. ImAge quantitates aging and rejuvenation. Nat Aging. 2024 Sep;4(9):1308-1327. doi: 10.1038/s43587-024-00685-1. Epub 2024 Aug 29. PMID: 39210148.
  100. Miller KN, Li B, Pierce-Hoffman HR, Patel S, Lei X, Rajesh A, Teneche MG, Havas AP, Gandhi A, Macip CC, Lyu J, Victorelli SG, Woo SH, Lagnado AB, LaPorta MA, Liu T, Dasgupta N, Li S, Davis A, Korotkov A, Hultenius E, Gao Z, Altman Y, Porritt RA, Garcia G, Mogler C, Seluanov A, Gorbunova V, Kaech SM, Tian X, Dou Z, Chen C, Passos JF, Adams PD. Linked regulation of genome integrity and senescence-associated inflammation by p53. BioRxiv. 2024 Sep 19; doi: 10.1101/2023.11.20.567963. PMCID: PMC10690201.
  101. Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD. Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence. Mol Cell. 2024 Sep 5;84(17):3271-3287.e8. doi: 10.1016/j.molcel.2024.08.006. Epub 2024 Aug 22. PMCID: PMC11390980.
  102. Jaber-Hijazi, F. Swaminathan, K, Gilroy, K, Wenzel, AT, Lagnado, A, Kirschner, K, Robertson,N, Reid, C, Fullarton, N, Pawlikowski, J, Blyth, K, Mesirov, JP, Rai TS, Passos, JF, Machesky, LM, Adams, PD (2022) Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells. bioRxiv 2022.04.22.489166; doi: https://doi.org/10.1101/2022.04.22.489166
  103. Chua Z, Rajesh A, Sinha S, Adams PD. PROTGOAT : Improved automated protein function predictions using Protein Language Models. BioRxiv. 2024 April. doi: https://doi.org/10.1101/2024.04.01.587572.
  104. Pourshafie N, Xu H, Yang K, Donahue G, Lei X, Zhang S, Shcherbakova O, Hogan C, Gilbert M, Hoxha K, Chaboub L, Lee V, Adams PD, Dani JA, Bonini N, Berger S. ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration. BioRxiv. 2024 March. doi: https://doi.org/10.1101/2024.03.27.586865.
  105. Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R. METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence. Nat Commun. 2024;15(1):5410. doi: 10.1038/s41467-024-49745-5. PMCID: PMC11208586.
  106. Byrns CN, Perlegos AE, Miller KN, Jin Z, Carranza FR, Manchandra P, Beveridge CH, Randolph CE, Chaluvadi VS, Zhang SL, Srinivasan AR, Bennett FC, Sehgal A, Adams PD, Chopra G, Bonini NM. Senescent glia link mitochondrial dysfunction and lipid accumulation. Nature. 2024; 630(8016):475-483. doi: 10.1038/s41586-024-07516-8. Epub 2024 Jun 5. Erratum in: Nature. 2024 Aug;632(8026):E8. doi: 10.1038/s41586-024-07904-0; PMCID: PMC11168935.
  107. Havas AP, Lande K, Rajesh A, Evensen KG, Varanasi SK, Shang L, Schmidt E, Lee J, Kim K, Teneche MG, Hoffmann F, Porte ML, Davis A, Grier A, Reisz JA, Tharp K, Gandhi A, Lei X, Proulx J, Miller KN, Sacco A, Shadel GS, Niedernhofer L, Feng G, D"Alessandro A, Kaech S, Williams A, Adams PD. Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer. BioRxiv. 2024 August. doi: https://doi.org/10.1101/2024.07.31.606057.

Reviews and Book Chapters

  1. Adams PD, Kaelin WG Jr. Transcriptional control by E2F. Semin Cancer Biol., 1995, 6:99-108. doi: 10.1006/scbi.1995.0013. PMID: 7647312.
  2. Adams, P.D., Kaelin, W.G. Jr. The cellular effects of E2F overexpression. In: Transcriptional Control of Cell Growth by the E2F Gene Family (Farnham P.J., ed.). Curr. Top. Microbiol. Immunol., 1996, 208:79-93. doi: 10.1007/978-3-642-79910-5_4. Review. PMID: 8575214.
  3. Adams, P.D., Lopez, P., Sellers, W.R., Kaelin, W.G., Jr. Fluorescence activated cell sorting of transfected cells. Meth. Enzymol., 1997, 283:59-72. doi: 10.1016/s0076-6879(97)83007-8. PMID: 9251011.
  4. Adams PD, Kaelin WG, Jr. Negative control elements of the cell cycle in human tumours. Curr. Opin. Cell. Biol. 1998, 10:791-797. doi: 10.1016/s0955-0674(98)80123-3. Review. PMID: 9914179.
  5. Harper JW, Adams PD. Cyclin-Dependent Kinases. In: Chemical Reviews, Protein Phosphorylation and Dephosphorylation (Ahn, N. ed.). The American Chemical Society , 2001, 101:2511-2526.
  6. Adams PD. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim. Biophys. Acta, 2001, 1471:M123-133.
  7. Adams PD, Ohh M. Cloning of associated proteins by co-immunoprecipitation. In: Molecular Cloning (Sambrook, J., Fritsch, E.F., Maniatis, T. eds.), 3rd Edition, Section 18.60-18.68. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001.
  8. Adams PD, Seeholzer S, Ohh M. Identification of Associated Proteins by Coimmunoprecipitation. In: Protein-Protein Interactions (Golemis, E., ed.), pp. 59-74. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2002.
  9. Ye X, Adams PD. Coordination of S-phase events and genome stability. Cell Cycle, 2003, 2:185-187.
  10. Adams PD, Cairns P. Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells. Cancer Biol Ther., 2003, 2:557-558. doi: 10.4161/cbt.2.5.588. PMID: 14614326.
  11. Ye X, Poustovoitov M, Santos H, Nelson DM, Adams PD. Biochemical analysis of the cell cycle and cell cycle checkpoints in transiently transfected cells after collection with magnetic beads. Methods Mol Biol., 2004, 281:261-270. doi: 10.1385/1-59259-811-0:261. PMID: 15220535.
  12. Poustovoitov M, Serebriiskii I, Adams PD. A two-step two-hybrid system to identify functionally significant protein-protein interactions. In: Methods: Analysis and Manipulation of Intracellular Signaling Cascades (Golemis, E.A., Chernoff, J., eds.). pp. 371-380. Elsevier Press, San Diego, CA, 2004. doi: 10.1016/j.ymeth.2003.10.012. PMID: 15003599.
  13. Adams PD. Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs. Methods Mol Biol., 2005, 296:189-196. doi: 10.1385/1-59259-857-9:189. PMID: 15576933.
  14. Adams PD, Golemis, E.A., (eds). Protein-Protein Interactions: A Molecular Cloning Manual, 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2005.
  15. Zhang R, Adams PD. Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle, 2007 Apr 1;6(7):784-789. doi: 10.4161/cc.6.7.4079. PMID: 17377503.
  16. Adams PD. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene, 2007, 397: 84-93. Invited review. PMCID: PMC2755200.
  17. Adams PD. Remodeling chromatin for senescence. Aging Cell, 2007, 6: 425-427, 2007. Invited Commentary. doi: 10.1111/j.1474-9726.2007.00313.x. PMID: 17635419.
  18. Zhang R, Adams PD, Ye X. Design and application of an shRNA-based gene replacement retrovirus. Methods Mol. Biol. In: Gene Function and Analysis. Ed. Michael F. Ochs. 408: 211-221, 2007.
  19. Adams P.D. Regulation of senescence by chromatin structure and E2F transcription factors. In Control of Cellular Physiology by Transcription Factors E2F. pp123-152. Research signpost, Ed. Yoshida, K. 2008. Invited review.
  20. Sedivy JM, Banumathy G, Adams PD. Aging by epigenetics - a consequence of chromatin damage? Experimental Cell Research, 2008, 314:1909-1917. PMCID: PMC2464300.
  21. Adams PD, Enders GH. Wnt-signaling and senescence: A tug of war in early neoplasia?. Cancer Biol Ther., 2008, 7:1706-1711. PMCID: PMC2783518.
  22. Adams, P.D. Regulation of oncogene-induced senescence by Wnt-signaling - a convergence on melanoma. Cell Technology, 2008, 27: 875-879. (Translated into Japanese).
  23. Simpson R, Adams PD, Golemis EA (eds). Basic Methods in Protein Purification and Analysis: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2008.
  24. Adams PD, Enders GH. Wnt-signaling and senescence: A tug of war in early neoplasia?. Cancer Biol Ther., 2008, 7:1706-1711. PMCID: PMC2783518.
  25. Adams PD. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Molecular Cell, 2009, 36: 1-14.
  26. Banumathy G, Adams PD. Chromatin in senescent cells: a conduit for the anti-aging effects of Wnt signaling? In: Epigenetics of aging. Springer Press. Tollefsbol, T.O. (Ed). pp77-106, 2010
  27. Banumathy, G. Adams, P.D. The secretome of senescent cells. In: Cellular senescence and tumor suppression. Springer Press. Adams, P.D., Sedivy, J.S. (Eds). pp109-124, 2010
  28. Adams, P.D., Sedivy, J.S. (Eds). Cellular senescence and tumor suppression. Springer Press. 2010
  29. Adams PD. The senescence secretome and its impact on tumor suppression and cancer. In: Cell cycle deregulation in cancer. Springer Press. Enders, G (Ed). pp139-156, 2010
  30. Cruickshanks HA, Adams PD. Chromatin: a molecular interface between aging and cancer. Curr. Op. Gen. Dev., 2011, 21:100-106. PMCID: PMC3895593.
  31. Ivanov A, Adams PD. A damage limitation exercise. Nat. Cell. Biol., 2011, 13:193-195, 2011. doi: 10.1038/ncb0311-193. PMID: 21364567.
  32. Rai TS, Adams PD. Lessons from senescence: chromatin maintenance in non-proliferating cells. Biochimica et Biophysica Acta. 2012, 1819:322-331. PMCID: PMC3895594.
  33. Kennedy AL, Adams PD, Morton JP. Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small GTPases, 2011, 2:264-267. PMCID: PMC3265817.
  34. van Tuyn, J., Adams, P.D. Signaling the end of the line. Nat. Cell. Biol., 2012, 14:339-341. doi: 10.1038/ncb2476. PubMed PMID: 22469830.
  35. Lund K, Adams PD, Copland M. EZH2 in normal and malignant hematopoiesis. Leukemia, 2014, 28:44-49. doi: 10.1038/leu.2013.288. PMID: 24097338.
  36. Pawlikowski J, Adams PD, Nelson DM. Senescence at a glance. J. Cell. Sci., 2013, 126:4061-4067. PMCID: PMC3772382.
  37. McBryan, T., Adams, P.D. Epigenetics. Introduction in “Handbook of Pharmacogenomics and Stratified Medicines”. S. Padmanabhan (Ed.), Elsevier, 2014.
  38. Adams PD, Jasper H, Rudolph KL. Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell, 2015 Jun 4;16(6):601-612. doi: 10.1016/j.stem.2015.05.002. PMID: 26046760
  39. Rai TS, Adams PD. ChIP-Sequencing to Map the Epigenome of Senescent Cells Using Benzonase Endonuclease. Methods Enzymol., 2016; 574:355-364. doi: 10.1016/bs.mie.2016.01.021. PMID: 27423868.
  40. Vizioli, M-G., Adams, P.D. Senescence Can Be BETter without the SASP? Cancer Discovery, 2016, 6:576-578. doi: 10.1158/2159-8290.CD-16-0485. PMCID: PMC6489500.
  41. Marmorstein R, Adams PD. Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA. Stem Cell Investig. 2017, 4:46. doi: 10.21037/sci.2017.05.08. eCollection. PMCID: PMC5460127.
  42. Field AE, Adams PD. Targeting chromatin aging - The epigenetic impact of longevity-associated interventions. Exp Gerontol. 2017, 94:29-33. doi: 10.1016/j.exger.2016.12.010. PMID: 27986499.
  43. Field AE, Robertson NA, Wang T, Havas A, Ideker T, Adams PD. DNA methylation clocks – categories, causes and consequences. Mol Cell., 2018, 71:882-895. doi: 10.1016/j.molcel.2018.08.008. PMID: 30241605.
  44. Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A. As time flies by: Investigating cardiac aging in the short-lived Drosophila model. Biochim Biophys Acta Mol Basis Dis., 2019, 1865:1831-1844. Review. PMCID: PMC6527462.
  45. Barbosa, K., Li, S., Adams, P.D., Deshpande, A.J. The Role of TP53 in Acute Myeloid Leukemia: Challenges and Opportunities. Genes, Chromosomes & Cancer, 2019, 58:875-888. doi: 10.1002/gcc.22796. Review. PMID: 31393631.
  46. Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D., Bischof, O., Bishop, C., Campisi, C., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A., Narita, M., Niedernhofer, L., Passos, J.F., Robbins, P.D., Schmitt, C.A., Sedivy, J.M., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M., Demaria, M. Cellular Senescence: Defining a Path Forward. Cell, 2019. 179: 813-827. doi: 10.1016/j.cell.2019.10.005. PMID: 31675495.
  47. Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck, S., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans, B.T., Horvath, S., Ideker, T., Issa, J-P.J., Kelsey, K.T., Marioni, R.E., Reik, W., Relton, C.L., Schalkwyk, L.C., Teschendorff, A.E., Wagner, W., Zhang, K., Rakyan, V. DNA methylation aging clocks: challenges and recommendations. Genome Biology, 2019, 20:249. PMCID: PMC6876109.
  48. Miller KN, Victorelli SG, Salmonowicz H, Dasgupta N, Liu T, Passos JF, Adams PD. Cytoplasmic DNA: sources, sensing, and role in aging and disease. Cell, 2021, 184:5506-5526. PMCID: PMC8627867.
  49. Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021, 43:2139-2148. PMCID: PMC8599742.
  50. Feng MW, Adams PD. A new mechanistic insight into fate decisions during yeast cell aging process. Mech Ageing Dev., 2021, 198:111542. PMCID: PMC8407526.
  51. Miller KN, Dasgupta N, Liu T, Adams PD, Vizioli MG. Cytoplasmic chromatin fragments-from mechanisms to therapeutic potential. Elife, 2021, Jan 29;10. doi: 10.7554/eLife.63728. PMCID: PMC7846272.
  52. Dasgupta N, Adams PD. Is aging a "Retro"spective event? Cell, 2023, 186:233-235. doi: 10.1016/j.cell.2022.12.040. PMID: 36669469.
  53. Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging, 2023, 3:776-790. PMID: 37400722
  54. Dasgupta N, Adams PD. Hematopoiesis: a BETter understanding. EMBO Rep. 2023; 24(10):e57927. doi: 10.15252/embr.202357927. Epub 2023 Aug 31. PMCID: PMC10561162.
  55. Li S, Adams PD. Targeting the epichaperome to combat AML. Blood. 2023;142(12):1031-1032. doi: 10.1182/blood.2023021386. PMID: 37733379.
  56. Nieto-Torres JL, Zaretski S, Liu T, Adams PD, Hansen M. Post-translational modifications of ATG8 proteins – an emerging mechanism of autophagy control. J.Cell Sci., 2023, 136: jcs259725. PMCID: PMC10445744.
  57. Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M. Guidelines for minimal information on cellular senescence experimentation in vivo. Cell. 2024,187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059. Review. PMID: 39121846.
  58. Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nat Rev Mol Cell Biol. 2024; doi: 10.1038/s41580-024-00738-8. [Epub ahead of print] Review. PMID: 38831121; NIHMSID:NIHMS2005833.
  59. Corveleyn L, Sen P, Adams P, Sidoli S. Linking Aging to Cancer: The Role of Chromatin Biology. J Gerontol A Biol Sci Med Sci. 2024;79(7). doi: 10.1093/gerona/glae133. Review. PMCID: PMC11170291.
  60. Dasgupta N, Arnold R, Equey A, Gandhi A and Adams PD, The Role of the Dynamic Epigenetic Landscape in Senescence: Orchestrating SASP Expression. NPJ Aging. 2024; 10(1):48. Review. PMCID: PMC11502686. doi: 10.1038/s41514-024-00172-2.