Peter Adams Lab

Epigenetics of Cancer and Aging

Publication List

Journal Publications

  1. Adams, P.D., Parker, P.J. TPA inducible activation of MAP-kinase. FEBS Lett. 290:77-82, 1991.
  2. Adams, P.D., Parker, P.J. Activation of MAP-kinase by a MAP-kinase-kinase. J. Biol. Chem. 267:13127 13130, 1992.
  3. Qin, X-Q., Livingston, D.M., Kaelin, W.G. Jr., Adams, P.D. Deregulated E2F-1 expression leads to S phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 91:10918-10922, 1994.
  4. Adams, P.D., Sellers, W.R., Sharma, S.K., Wu, A.D., Nalin, C.M., Kaelin, W.G. Jr. Identification of a Cyclin-Cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol. 16:6623-6633, 1996.
  5. Soucek, T., Pusch, O., Hengstschlager-Ottnad, E., Adams, P.D., Hengstschlager, M. Deregulated expression of E2F1 induces cyclin A and E associated kinase activities independently from cell cycle position. Oncogene 14:2251-2257, 1997.
  6. Kiley, S.C., Adams, P.D., Parker, P.J. Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants. Cell Growth Differ. 8:221-230, 1997.
  7. Adams, P.D., Li, X., Sellers, W.R., Baker, K.B., Leng, X., Harper, J.W., Taya, Y., Kaelin, W.G. Jr. The retinoblastoma protein contains a C terminal motif that targets it for phosphorylation by cyclin/cdk complexes. Mol. Cell. Biol. 19:1068-1080, 1999.
  8. Chen, Y-N. P., Sharma, S.K., Ramsey, T.M., Jiang, L., Martin, M.S., Baker, K., Adams, P.D., Bair, K.W., Kaelin, W.G., Jr. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc. Natl. Acad. Sci. USA 96:4325-4329, 1999.
  9. Ma, T., Van Tine, B.A., Wei, Y., Garrett, M.D., Nelson, D., Adams, P.D., Wang, J., Qin, J., Chow, L.T., Harper, J.W. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14:2298-2313, 2000.
  10. Miyake, S., Sellers, W.R., Safran, M., Li, X., Zhao, W., Grossman, S.R., Gan, J., DeCaprio, J.A., Adams, P.D., Kaelin, W.G. Jr. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol. Cell. Biol. 20:8889-8902, 2000.
  11. Hall, C., Nelson, D.M., Ye, X., Baker, K., DeCaprio, J.A., Seeholzer, S., Lipinski, M., Adams, P.D. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin/cdk2 substrate whose expression blocks S-phase progression. Mol. Cell. Biol. 21:1854-1865, 2001.
  12. Leng, X., Noble, M., Adams, P.D., Qin, J., Harper, J.W. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol. 22:2242-2254, 2002.
  13. Khare, L., Astrinidis, A., Senapedis, W., Adams P.D., Henske E.P. Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells. J. Med. Genet. 39:676-680, 2002.
  14. Nelson, D.M., Ye, X., Hall, C., Santos, S., Ma, T., Kao, G.D., Yen, T.J., Harper, J.W.. Adams, P.D. Coupling of DNA synthesis and histone synthesis in S-phase independent of cyclin/cdk2 activity. Mol. Cell. Biol. 22:7459-7472, 2002.
  15. Ye, X., Franco, A.A., Santos, H., Nelson, D.M., Kaufman, P.D., Adams, P.D. Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Molecular Cell. 11:341-351, 2003.
  16. Daganzo, S.M., Erzberger, J.P., Lam, W.M., Skordalakes, E., Zhang, R., Franco, A.A., Brill, S.J., Adams, P.D., Berger, J.M., Kaufman P.D. Structure and function of the conserved core of histone deposition protein Asf1. Curr. Biol. 13:2148-2158, 2003.
  17. Zhang, R., Poustovoitov, M.V., Ye, X., Santos, H.A., Chen, W., Daganzo, S.M., Erzberger, J.P., Serebriiskii, I.G., Canutescu, A.A., Dunbrack, R.L., Pehrson, J.R., Berger, J.M., Kaufman, P.D., Adams, P.D. Formation of macroH2A-containing senescence associated heterochromatin foci (SAHF) and senescence driven by ASF1a and HIRA. Developmental Cell 8:19-30, 2005.
  18. Nagamori, I., Yomgida, K., Adams, P.D., Sassone-Corsi, P., Nojima, H. Transcription Factors, cAMP-responsive Element Modulator (CREM) and Tisp40, Act in Concert in Postmeiotic Transcriptional Regulation. J Biol Chem. 281:15073-15081, 2006.
  19. Tang, Y., Poustovoitov, M.V., Zhao, K., Garfinkel, M., Canutescu, A., Dunbrack, R., Adams, P.D.*, Marmorstein, R.* Structure of a human ASF1a/HIRA complex and insights into specificity of histone chaperone complex assembly. Nature Struct. Mol. Biol. 13:915-920, 2006. *Corresponding authors.
  20. Zhang, R., Liu, S.T., Chen, W., Bonner, M., Pehrson, J., Yen, T.J., Adams, P.D. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol. Cell Biol. 27:949-962, 2007.
  21. Zhang, R., Chen, W., Adams, P.D. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 27:2343-2358, 2007.
  22. Ye, X., Zerlanko, B., Zhang, R., Somiah, N., Lipinski, M., Salomoni, P., Adams, P.D. Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol. Cell Biol. 27:2452-2465, 2007.
  23. Ye X., Zerlanko B., Kennedy, A., Banumathy, G., Zhang R., Adams P.D. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Molecular Cell. 27:183-196, 2007.
  24. Poleshko, A., Palagin, I., Zhang, R., Boimel, P., Castagna, C., Adams, P.D., Skalka, A.M., Katz, R.A. Identification of Cellular Proteins That Maintain Retroviral Epigenetic Silencing: Evidence for an Antiviral Response. J. Virology. 82 : 2313-2323 2008.
  25. Ambagala, A., Bosma, T., Ali, M., Poustovoitov, M., Gershon, M.D. Adams, P.D., Cohen, J.I., VZV Immediate-Early 63 Protein Interacts with Human Anti-Silencing Function 1 Protein and Alters its Ability to Bind Histones H3.1 and H3.3. J. Virology. 83:200-9, 2008
  26. Banumathy, G., Somaiah, N., Zhang, R., Schultz, D., Andrake, M., Ceulemans, H., Adams, P.D. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol. Cell. Biol. 29:758-70, 2009
  27. Poleshko A., Einarson M.B., Shalginskikh N., Zhang R, Adams P.D., Skalka A.M., Katz R.A. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. Oct 30, 2009.
  28. Kennedy, A.L., McBryan, T., Enders, G.H., Johnson, F.B., Zhang, R., Adams, P.D. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. BMC Cell Division. Jun 22;5:16, 2010.
  29. Kreiling, J.A., Tamamori-Adachi, M., Sexton, A.N., Jeyapalan, J.C., Munoz-Najar, U., Peterson, A.L., Jayameenakshi, M., Rogers, E.S., Pchelintsev, N.A., Adams, P.D., Sedivy, J.M. Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell. 10: 292-304. 2011
  30. Kennedy, A.L., Morton, J.P., Jamieson, N.B., Manoharan, I., McBryan, T., Doyle, B., Oien, K.A., Enders, G.H., Zhang, R., Sansom, O.J., Adams, P.D. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol. Cell. 42: 36-49. 2011.
  31. Rai, T.S., Puri, A., McBryan, T., Hoffman, J., Tang, Y., Pchelintsev, N., van Tuyn, J., Marmorstein, R., Schultz, D.C., Adams, P.D. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol. Cell. Biol., 31:4107-18, 2011.
  32. Ray-Gallet, D., Woolfe, A., Vassias, I., Pellentz, C., Lacoste, N., Puri, A., Schultz, D.C., Pchelintsev, N.A., Adams, P.D., Jansen, L.E.T., Almouzni, G. A crosstalk between H3.3 and H3.1 in vivo and alternative modes for HIRA-dependent H3.3 deposition. Mol. Cell., 44:928-41, 2011.
  33. Tang, Y., Puri, A., Ricketts, M., Rai, T., Hoffmann, J., Hoi, E., Adams, P.D., Schultz, D., Marmorstein, R. Identification of an Ubinuclein 1 region required for stability of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry, 51:2366-77, 2012.
  34. Moyes, L.H., McEwan, H., Radulescu, S., Pawlikowski, J., Lamm, C.G., Nixon, C., Sansom, O.J., Going, J. J., Fullarton, G. M., Adams, P.D. Activation of Wnt Signalling promotes development of dysplasia in Barrett's Oesophagus. J. Pathology, 228:99-112, 2012
  35. Dekker, P., Gunn, G., McBryan, T., Dirks, R.W., van Heemst, D., Lim, F-L., Jochemsen, A.G., Verlaan-de Vries, M., Nagel, J., Adams, P.D., Tanke, H.J., Westendorp, R.G., Maier, A.B. Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts. Mech. Aging and Dev, 133:498-507, 2012
  36. Sawicka, M., Pawlikowski, J., Wilson, S., Ferdinando, D., Wu, W., Adams, P.D., Gunn, D., Parish, W. The Specificity and Patterns of Staining in Human Cells and Tissues of p16INK4a Antibodies Demonstrate Variant Antigen Binding. PLoS One. 2013;8(1):e53313. doi: 10.1371/journal.pone.0053313. Epub 2013 Jan 8.
  37. Howard, L., Mackenzie, R.M., Pchelintsev, N.A., McBryan, T., McClure, J.D., McBride, M.W., Kane, N., Adams, P.D., Milligan, G., Baker, A.H., Profiling of Transcriptional & Epigenetic Changes During Directed Endothelial Differentiation of Human Embryonic Stem Cells Identifies FOXA2 as a Marker of Early Mesoderm Commitment. Stem Cell Res Ther. 2013 Apr 24;4(2):36.
  38. Pchelintsev, N.A., McBryan, T., Lake, R.J., Rai, T.S., van Tuyn, J., Puri, A., Tang, Y., Ray-Gallet, D., Almouzni, G.A., Schultz, D.C., Marmorstein, R., Fan, H-Y., Adams, P.D. Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Reports, April 18, 2013.
  39. Ivanov, A., Pawlikowski, J., Manoharan, I., Rai, T. S., Nelson, D. M., Shah, P. P., Drotar, M., Wu, H., Berger, S. L., and Adams, P. D. Lysosome-dependent processing of histones in senescent cells. J. Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1.
  40. Shah, P.P., Donahue, G., Nelson, D.M., Cruickshanks, H., McBryan, T., Cao, K., Aggarwala, V., Adams, P.D.*, Berger, S.L.* Lamin B1 Depletion in Senescent Cells Leads to Large-Scale Changes in the Chromatin Landscape. Genes and Development. 2013 Aug 15;27(16):1787-99. doi: 10.1101/gad.223834.113. Epub 2013 Aug 9. *Corresponding authors.
  41. Pawlikowski J.S., McBryan T., van Tuyn J., Drotar M.E., Hewitt R.N, Maier A.B., King A., Blyth K., Wu H., Adams P.D. Wnt signaling potentiates nevogenesis. Proc. Natl. Acad. Sci. 2013 Oct 1;110(40):16009-16014. PMID: 24043806
  42. Cruickshanks, H., McBryan, T., Nelson, D.M., VanderKraats, N.D., Shah, P., van Tuyn, J., Rai, T.S., Brock, C., Donahue, G., Dunican, D.S., Drotar, M.E., Meehan, R.R., Edwards, J.R., Berger, S. L., and Adams, P.D. Senescent cells harbor features of the cancer epigenome. Nat. Cell Biol. 2013 Nov 24. doi: 10.1038/ncb2879.
  43. Rosenfeldt, M., O'Prey, J., Morton, J., Nixon, C., Mackay, G., Mrowinska, A., Au, A., Rai, T.S., Zheng, L., Ridgway, R., Adams, P.D., Anderson, K., Gottlieb, E., Sansom, O., Ryan, K. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013 Dec 4. doi: 10.1038/nature12865.
  44. Hofmann J.W., McBryan T., Adams P.D., Sedivy J.M. The effects of aging on the expression of Wnt pathway genes in mouse tissues. Age. 2014 Feb 1.
  45. Haas N.B., Quirt I., Hotte S., McWhirter E., Polintan R., Litwin S., Adams P.D., McBryan T., Wang L., Martin L.P., vonMehren M., Alpaugh R.K., Zweibel J., Oza A. Phase II trial of Vorinostat in advanced melanoma. Investigational New Drugs. 2014 Jan 25.
  46. Nelson DM, McBryan T, Jeyapalan JC, Sedivy JM, Adams PD., Comparative gene expression profiling reveals similarities and differences between oncogene-induced senescence and replicative senescence. Age (Dordr). 2014 Jun;36(3):9637. doi: 10.1007/s11357-014-9637-0. Epub 2014 Mar 20.
  47. Lund, K, Cole, J., VanderKraats, N.D, McBryan, T., Pchelintsev, N.A., Clark, W., Copland, M., Edwards, J.R., Adams, P.D. DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in Acute Myeloid Leukemia. Genome Biology, 2014, 15:406
  48. Soni, S., Pchelintsev, N. A., Adams, P.D., Bieker, J.J., EKLF/KLF1 recruitment of HIRA is essential for b-globin gene expression. Proc. Natl. Acad. Sci., 2014 Sep 2. pii: 201405422. [Epub ahead of print]
  49. Rai, T.S., Cole, J.C., Nelson, D.M., Dikovskaya, D., McBryan, T., Faller, W., van Tuyn, J., Morrice, N., Hewitt, R.N., Manoharan, I., Pchelintsev, N.A., Ivanov, A., Brock, C., Drotar, M.E., Nixon, C., Clark, W., Sansom, O.J., King, A., Blyth, K., Adams, P.D. HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes Dev. 2014, 28:2712-25. doi: 10.1101/gad.247528.114.
  50. Pawlikowski, J.S., Brock, C., Chanudet, E., Paine, S., Nixo, C., McGregor, F., Lambie, W., Holmes, W., Mullin, J., Wu, H., Blyth, K., King, A., Kinsler, V.A, Adams, P.D. Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a novel murine model driven by activated NRAS and Wnt. J. Invest. Dermatol., 2015 Mar 27. doi: 10.1038/jid.2015.114. [Epub ahead of print] PMID: 25815427
  51. Ricketts, M.D., Rai, T.S., Frederick, B.,Hoff, H., Tang, Y., Schultz, D.S., Adams, P.D., Marmorstein, R. Ubinuclein-1 confers histone H3.3-specific binding specificity by the HIRA histone chaperone complex. Nat. Comms., 2015 Jul 10;6:7711. doi: 10.1038/ncomms8711.
  52. Waaijer, M.E.C., Gunn, D.A., Adams, P.D., Pawlikowski, J.S., Griffiths, C.E.M., van Heemst, D., Slagboom, P.E., Westendorp, R.G.J., Maier, A.B. P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences., 2015;
doi: 10.1093/gerona/glv114
  53. Dikovskaya, D., Cole, J.J., Mason, S.M., Nixon, C., Karim, S.A., McGarry, L., Clark, W., Hewitt, R.N., Sammons, M.A, Zhu, J., Athineos, D., Leach, J.D.G., Marchesi, F., van Tuyn, J., Tait, S.W., Brock, C., Morton, J.P., Wu, H., Berger, S.L., Blyth, K., Adams, P.D. Oncogene-induced mitotic stress generates multinucleate senescent cells and impacts tumor suppression. Cell Reports,
  54. Dou, Z., Capell, BC., Drake, AM., Shah, PP., Dorsey, J., Simola, D., Donahue, G., Zhu, Z., Sammons, M., Rai, TS., Natale, C., Ridky, T., Goldman, R., Adams, PD., Berger, SL. Autophagy mediates degradation of nuclear lamina. Nature, 2015, 527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28.
  55. Maddocks, ODK., Labuschagne, CF., Adams, PD., Vousden, K., Serine metabolism supports the methionine cycle and DNA / RNA methylation through de novo ATP synthesis in cancer cells. Mol Cell, 2016, 61:210-21. doi: 10.1016/j.molcel.2015.12.014.
  56. Correia-Melo, C., Marques, FDM., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, BM., Miwa, S., Merz, A., Rushton, MD.,, Charles, M., Jurk, D., Tait, SW., Czapiewski, R., Birch, J., Greaves, L., Nelson, G., Bohlooly-Y, M., Vidal-Puig, A., Rodriguez-Cuenca, S., Mann, D., Saretzki, G., Adams, PD., von Zglinicki, T., Korolchuk, VI., Passos, JF. Mitochondria are required for the pro-aging features of the senescent phenotype. EMBO J., 2016, 35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.
  57. Capell, BC., Drake, AM., Shah, PP., Dorsey, J., Simola, D., Donahue, G., Dou, Z., Zhu, Z., Sammons, M., Rai, TS., Natale, C., Ridky, T., Adams, PD., Berger, SL. MLL1 epigenetically regulates expression of ATM and the senescence-associated secretory phenotype. Genes Dev., 2016, Feb 1;30(3):321-36. doi: 10.1101/gad.271882.115.
  58. Nelson, D.M., Adams, P.D., Pchelintsev, N., Critical parameters for efficient sonication and improved chromatin immunoprecipitation of high molecular weight proteins. PLoS One, 2016, 11(1):e0148023. doi: 10.1371/journal.pone.0148023. eCollection 2016.
  59. Nelson, D.M., Jaber-Hijazi, F., Cole, J.J., Robertson, N.A., Pawlikowski, J.S., Norris, K.T., Criscione, S.W., Pchelintsev, N.A., Piscitello, D., Stong, N., Rai, T.S., McBryan, T., Otte, G.L., Nixon, C., Clark, W., Riethman, H., Wu, H., Schotta, G., Garcia, B.A., Neretti, N., Baird, D., Berger, S.L., Adams, P.D. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. PMID: 27457071.
  60. Cole, J.J., Robertson, N.A., Rather, M.I., Thomson, J.P., McBryan, T. Sproul, D. Wang, T. Brock, C; Clark, W., Ideker, T. Meehan, R.R. Miller, R.A., Brown-Borg, H., Adams, P.D. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biol. 2017 Mar 28;18(1):58. doi: 10.1186/s13059-017-1185-3. PMCID: PMC5370462.
  61. Wang, T., Tsui, B., Kreisberg, J.F., Robertson, N.A., Gross, A.M., Carter, H., Brown-Borg, H., Adams, P.D, Ideker, T. Epigenetic aging signatures in mice are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biol. 2017 Mar 28;18(1):57. doi: 10.1186/s13059-017-1186-2. PMCID: PMC5371228.
  62. van Tuyn, J., Jaber-Hijazi, F., MacKenzie, D., Cole, J.J., Mann, E., Pawlikowski, J.S., Rai, T.S., Nelson, D.M., McBryan, T., Ivanov, A., Blyth, K., Wu, H., Milling, S., Adams, P.D. Oncogene-Expressing Senescent Melanocytes Upregulate MHC Class II, A Candidate Melanoma Suppressor Function. J. Invest. Derm. 2017 Jun 21. doi:10.1016/j.jid.2017.05.030.
  63. Leung, E.Y., McMahon, J.D., McLellan, D., Syyed, N., McCarthy, C.E., Nixon, C., Orange, C., Brock, C., Hunter, K. and Adams, P.D. DNA damage marker phosphorylated histone H2AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity. Histopathology. 2017 May 19. doi: 10.1111/his.13260.
  64. Rai, T.S., Glass, M., Cole, J., Rather, M.I., Marsden, M., Neilson, M., Humphreys, I., Everett, R., Adams, P.D. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Res. 2017 Sep 13. doi: 10.1093/nar/gkx771. [Epub ahead of print]
  65. Dou, Z., Ghosh, K., Vizioli, M.G., Zhu, J., Sen, P., Wangensteen, K.J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., Capell, B.C., Xu, C., Xu, M., Kieckhaefer, J.E., Jiang, T., Shoshkes-Carmel, M., Ahasan Al Tanim, K.M., Barber, G.N., Seykora, J.T., Millar, S.E., Kaestner, K.H., Garcia, B.A., Adams, P.D.* and Berger, S.L.* Cytoplasmic Chromatin Triggers Inflammation in Senescence and Cancer. Nature. 2017 Oct 4. doi: 10.1038/nature24050. [Epub ahead of print]. *Corresponding Authors.
  66. Piscitello, D., Varshney, D., Lilla, S., Vizioli, MG., Brock, C., Gorbunova, V., Seluanov, A., Gillespie, D.A., Adams, P.D. AKT overactivation Can Suppresses DNA Repair via p70S6 Kinase-mediated MRE11 downregulation. Oncogene. 2017 Oct 2. doi: 10.1038/onc.2017.340.
  67. Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. A role for p53 in the adaption to glutamine starvation through the expression of SLC1A3. Cell Metab. 2018 Aug 8. pii: S1550-4131(18)30448-0. doi: 10.1016/j.cmet.2018.07.005.
  68. Guida, M., Birse, R., Dall'Agnese, A., Coutinho, P., Diop, S., Mai, A., Adams, P.D., Puri, PL., Bodmer, R. Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila. Nat Commun. 2019 Jan 14;10(1):193. doi: 10.1038/s41467-018-08128-3. PubMed PMID: 30643137; PubMed Central PMCID: PMC6331650.
  69. Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L., Kolsky, K.L., Parini, A., Douin-Echinard, V., LeBrasseur, N.K., Arthur, H.M., Tual-Chalot, S., Schafer, M.J., Roos, C., Miller, J., Robertson, N., Mann, J., Adams, P.D., Tchkonia, T., Kirkland, J.L., Mialet-Perez, J., Richardson, G.D., Passos, J.F. Length-independent telomere damage drives cardiomyocyte senescence. EMBO J. 2019 Mar 1;38(5). doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. PubMed PMID: 30737259; PubMed Central PMCID: PMC6396144.
  70. Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, Kiourtis C, Müller M, Green AR, Adams PD, Acosta JC, Bird TG, Kirschner K, Neretti N, Chandra T. Notch Signaling Mediates Secondary Senescence. Cell Rep. 2019 Apr 23;27(4):997-1007.e5. doi: 10.1016/j.celrep.2019.03.104. PubMed PMID: 31018144; PubMed Central PMCID: PMC6486482.
  71. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. PubMed PMID: 30773298.
  72. M. Daniel Ricketts, Nirmalya Dasgupta, Jiayi Fan, Joseph Han, Morgan Gerace, Yong Tang, Ben E. Black, Peter D. Adams and Ronen Marmorstein. The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity. Journal of Biological Chemistry 2019 doi: 10.1074/jbc.RA119.007480
  73. Costa, T., Zhuang, T., Lorent, J., Turco, E., Olofsson, H., Masia-Balague, M., Zhao, M., Rabieifar, P., Robertson, N., Kuiper, R., Sjölund, J., Spiess, M., Hernandez-Varas, P., Rabenhorst, U., Roswall, P., Ma, R., Gong, X., Hartman, J., Pietras, K., Adams, PD., Defilippi, P., Strömblad, S., PAK4 suppresses RELB to prevent senescence-likegrowth arrest in breast cancer. Nat. Comms. 2019. 10:3589.
  74. Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., Pawlikowski, J.S., Jurk ,D., Adams, P.D., van Heemst, D., Beekman, M., Slagboom, P.E., Gunn, D.A., Passos, J.F. Senescent melanocytes drive skin aging via paracrine telomere dysfunction. EMBO J (2019)e101982
  75. McFarlane, S., Orr, A., Roberts, A.P.E., Conn, K.L., Iliev, V., Loney, C., Filipe, A da S., Smollett, K., Gu, Q., Robertson, N., Adams, P.D., Singh Rai, T., Boutell, C. The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. PLOS Pathogens. 2019.
  76. Douglas J. MacKenzie, Neil A. Robertson, Iqbal Rather, Claire Reid, Gintare Sendzikaite, Hazel Cruickshanks, Tony McBryan, Andrew Hodges, Catrin Pritchard, Karen Blyth, and Adams, P.D.. DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience. 2020 Jan 14;23(2):100838. doi:10.1016/j.isci.2020.100838
  77. Casciano J.C., Perry C., Cohen-Nowak A.J., Miller K.D., Vande Voorde J., Zhang Q., Chalmers S., Sandison M.E., Liu Q., Hedley A., McBryan T., Tang H.Y., Gorman N., Beer T., Speicher D.W., Adams P.D., Liu X., Schlegel R., McCarron J.G., Wakelam M.J.O., Gottlieb E., Kossenkov A.V., Schug Z.T. MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. Br J Cancer. 2020 Jan 16. doi: 10.1038/s41416-019-0711-3
  78. Maria Grazia Vizioli, Tianhui Liu, Karl N. Miller, Neil A. Robertson, Kathryn Gilroy, Anthony B. Lagnado, Arantxa Perez-Garcia, Christos Kiourtis, Nirmalya Dasgupta, Xue Lei, Patrick J. Kruger, Colin Nixon, William Clark, Diana Jurk, Thomas G. Bird, João F. Passos, Shelley L. Berger, Zhixun Dou, and Adams, P.D.. Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence, 2020 Jan 30. Genes Dev. 2020;10.1101/gad.331272.119. doi:10.1101/gad.331272.119
  79. Chao Chen, Ming-an Sun, Claude Warzecha, Mahesh Bachu, Anup Dey, Tiyun Wu, Adams P.D., Todd Macfarlan, Paul Love, and Keiko Ozato. HIRA, a DiGeorge Syndrome Candidate Gene, ConfersProper Chromatin Accessibility on HSCsand Supports All Stages of Hematopoiesis. Cell Reports 2020 Feb 18.
  80. Wang, T., Ma, J., Hogan, A.N., Fong, S., Licon, K., Tsui, B., Kreisberg, J.F., Adams, P.D., Carvunis, A-R., Bannasch, D., Ostrander, E.A., Ideker, T., Quantitative translation of dog to human aging by conserved remodeling of epigenetic networks. Cell Syst. 2020 Jul 1:S2405-4712(20)30203-9. doi: 10.1016/j.cels.2020.06.006. Online ahead of print.
  81. Xu, C., Wang, L., Fozouni, P., Evjen, G., Chandra, V., Jiang, J., Lu, C., Nicastri, M., Bretz, C., Winkler, J.D., Amaravadi, R., Garcia, B.A., Adams, P.D., Ott, M., Tong, W., Johansen, T., Dou, Z., Berger, S.L., SIRT1 is downregulated by autophagy in senescence and aging. Nat. Cell. Biol. 2020. 22, pages1170–1179. doi: 10.1038/s41556-020-00579-5
  82. Latif AL, Newcombe A, Li S, Gilroy K, Robertson NA, Lei X, Stewart HJS, Cole J, Terradas MT, Rishi L, McGarry L, McKeeve C, Reid C, Clark W, Campos J, Kirschner K, Davis A, Lopez J, Sakamaki JI, Morton JP, Ryan KM, Tait SWG, Abraham SA, Holyoake T, Higgins B, Huang X, Blyth K, Copland M, Chevassut TJT, Keeshan K, Adams PD. BRD4-mediated repression of p53 is a target for combination therapy in AML. Nat Commun. 2021 Jan 11;12(1):241. doi: 10.1038/s41467-020-20378-8. PMID: 33431824; PMCID: PMC7801601.
  83. Narayanan, S.P., O’Brien, D., Sharma, M., Miller, K., Adams, P.D., Passos, J.F., Eirin, A., Ordog, T., Bharucha, A.E. Duodenal mucosal mitochondrial gene expression is associated with delayed gastric emptying in diabetic gastroenteropathy. JCI Insight. 2021 6(2):e143596. https://doi/10.1172/jci.insight.143596
  84. Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. Blood. 2021 Jun 17;137(24):3403-3415. doi: 10.1182/blood.2020009023. PMID: 33690798; PMCID: PMC8212510.
  85. Gerber JP, Russ J, Chandrasekar V, Offermann N, Lee HM, Spear S, Guzzi N, Maida S, Pattabiraman S, Zhang R, Kayvanjoo AH, Datta P, Kasturiarachchi J, Sposito T, Izotova N, Händler K, Adams PD, Marafioti T, Enver T, Wenzel J, Beyer M, Mass E, Bellodi C, Schultze JL, Capasso M, Nimmo R, Salomoni P. Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation. Nat Cell Biol. 2021 Dec;23(12):1224-1239. doi: 10.1038/s41556-021-00774-y. Epub 2021 Dec 7.PMID: 34876685

Reviews and Book Chapters

  1. Adams, P.D., Kaelin, W.G. Jr. Transcriptional control by E2F. Sem. Cancer Biol. 6:99-108, 1995.
  2. Adams, P.D., Kaelin, W.G. Jr. The cellular effects of E2F overexpression. In: Transcriptional Control of Cell Growth by the E2F Gene Family (Farnham P.J., ed.). Curr. Top. Microbiol. Immunol. 208:79-93, 1996.
  3. Adams, P.D., Lopez, P., Sellers, W.R., Kaelin, W.G., Jr. Fluorescence activated cell sorting of transfected cells. Meth. Enzymol. 283:59-72, 1997.
  4. Adams, P.D., Kaelin, W.G., Jr. Negative control elements of the cell cycle in human tumours. Curr. Opin. Cell. Biol. 10:791-797, 1998.
  5. Adams, P.D., Ohh, M. Cloning of associated proteins by co-immunoprecipitation. In: Molecular Cloning (Sambrook, J., Fritsch, E.F., Maniatis, T. eds.), 3rd Edition, Section 18.60-18.68. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001.
  6. Adams, P.D. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim. Biophys. Acta 1471:M123-133, 2001.
  7. Harper, J.W., Adams, P.D. Cyclin-Dependent Kinases. In: Chemical Reviews, Protein Phosphorylation and Dephosphorylation (Ahn, N. ed.). The American Chemical Society 101:2511-2526, 2001.
  8. Adams P.D., Seeholzer S., Ohh, M. Identification of Associated Proteins by Coimmunoprecipitation. In: Protein-Protein Interactions (Golemis, E., ed.), pp. 59-74. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2002.
  9. Ye, X., Adams, P.D. Coordination of S-phase events and genome stability. Cell Cycle 2:185-187, 2003.
  10. Adams, P.D., Cairns, P. Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells. Cancer Biol. Ther. 2:557-558, 2003.
  11. Ye, X., Poustovoitov, M., Santos, S., Nelson, D.M., Adams P.D. Biochemical analysis of the cell cycle and cell cycle checkpoints in transiently transfected cells after collection with magnetic beads. Methods Mol. Biol., 281:261-270, 2004.
  12. Poustovoitov, M., Serebriiskii, I., Adams, P.D. A two-step two-hybrid system to identify functionally significant protein-protein interactions. In: Methods: Analysis and Manipulation of Intracellular Signaling Cascades (Golemis, E.A., Chernoff, J., eds.). pp. 371-380. Elsevier Press, San Diego, CA, 2004.
  13. Adams, P.D. Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs. Methods Mol. Biol. 296:189-196, 2004.
  14. Cairns, P., Adams, P.D. Clipped wings: Epigenetic inactivation of APC. Cancer Biol. Ther. 3:965-966, 2004.
  15. Adams, P.D., Golemis, E.A., (eds). Protein-Protein Interactions: A Molecular Cloning Manual, 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2005.
  16. Zhang, R., Adams, P.D. Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle 6:784-789, 2007.
  17. Adams P.D. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene. Invited review. 397: 84-93, 2007.
  18. Adams, P.D. Remodeling chromatin for senescence. Invited Commentary. Aging Cell 6: 425-427, 2007.
  19. Zhang, R., Adams, P.D., Ye, X. Design and application of an shRNA-based gene replacement retrovirus. Methods Mol. Biol. In: Gene Function and Analysis. Ed. Michael F. Ochs. 408: 211-221, 2007.
  20. Adams P.D. Regulation of senescence by chromatin structure and E2F transcription factors. Invited review in Control of Cellular Physiology by Transcription Factors E2F. pp123-152. Research signpost, Ed. Yoshida, K., 2008.
  21. Sedivy, J.M., Banumathy, G. Adams, P.D. Aging by epigenetics - a consequence of chromatin damage? Experimental Cell Research. 314 : 1909-17, 2008
  22. Adams, P.D. Regulation of oncogene-induced senescence by Wnt-signaling - a convergence on melanoma. Cell Technology. 27: 875-879, 2008. (Translated into Japanese).
  23. Adams, P.D., Enders, G.H. Wnt signaling and senescence: a tug of war in early neoplasia? Cancer Biology and Therapy. 7: 1706 - 1711, 2008.
  24. Adams, P.D. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Molecular Cell. 36: 1-14, 2009.
  25. Banumathy, G. Adams, P.D. Chromatin in senescent cells: a conduit for the anti-aging effects of Wnt signaling? In: Epigenetics of aging. Springer Press. Tollefsbol, T.O. (Ed). pp77-106, 2010
  26. Banumathy, G. Adams, P.D. The secretome of senescent cells. In: Cellular senescence and tumor suppression. Springer Press. Adams, P.D., Sedivy, J.S. (Eds). pp109-124, 2010
  27. Adams, P.D., Sedivy, J.S. (Eds). Cellular senescence and tumor suppression. Springer Press. 2010
  28. Adams, P.D. The senescence secretome and its impact on tumor suppression and cancer. In: Cell cycle deregulation in cancer. Springer Press. Enders, G (Ed). pp139-156, 2010
  29. Cruickshanks, H. A and Adams, P.D. Chromatin: a molecular interface between aging and cancer. Curr. Op. Gen. Dev. 21: 100-6. 2011
  30. Ivanov, A., Adams, P.D. A damage limitation exercise. Nat. Cell. Biol. 13: 193-5. 2011
  31. Rai, TS., and Adams, P.D. Lessons from senescence: chromatin maintenance in non-proliferating cells. Biochimica et Biophysica Acta. Aug 3, 2011.
  32. Kennedy, A.L., Adams, P.D., Morton, J.P. Ras, PI3K/Akt and senescence: paradoxes provide clues for pancreatic cancer therapy. Small GTPases. 2: 264-267, 2011.
  33. van Tuyn, J., Adams, P.D. Signaling the end of the line. Nat. Cell. Biol., 14:339-41, 2012.
  34. Lund, K., Adams, P.D. Copland, M. Spotlight on EZH2 in normal and malignant hematopoiesis. Leukemia, In press.
  35. Pawlikowski, J., Adams, P.D., Nelson, D.M. Senescence at a glance. J. Cell. Sci. 126: 4061-7. doi: 10.1242/jcs.109728, 2013. PMID: 23970414
  36. McBryan, T., Adams, P.D. Epigenetics. Introduction in “Handbook of Pharmacogenomics and Stratified Medicines”. S. Padmanabhan (Ed.), Elsevier, 2014.
  37. Adams, P.D., Jasper, H., Rudolph, K.L., Aging-induced stem cell mutations as drivers for disease and cancer. Cell Stem Cell, 2015 Jun 4;16(6):601-612. doi: 10.1016/j.stem.2015.05.002. PMID: 26046760
  38. Rai, T.S., Adams, P.D. ChIP-sequencing to map the epigenome of senescent cells using Benzonase endonuclease. Methods in Enzymology, Vol. 574, Enzymes of Epigenetics, Part B, 2016. Edited by Ronen Marmorstein.
  39. Vizioli, M-G., Adams, P.D. Senescence Can Be BETter without the SASP? Cancer Discovery, 6:576-8, 2016. doi: 10.1158/2159-8290.CD-16-0485.
  40. Marmorstein, R., Adams, P.D., Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA. Stem Cell Investigation. In press. doi: 10.21037/sci.2017.05.08

  41. Field AE, Adams PD., Targeting chromatin aging - The epigenetic impact of longevity-associated interventions. Exp Gerontol. 2017 Aug;94:29-33. doi: 10.1016/j.exger.2016.12.010. Epub 2016 Dec 13.PMID: 27986499
  42. Field, A.E., Robertson, N.A., Wang, T., Havas, A., Ideker, T., Adams, P.D. DNA methylation clocks - categories, causes and consequences. Molecular Cell. 2018 Sep 20
  43. Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D., Bischof, O., Bishop, C., Campisi, C., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A., Narita, M., Niedernhofer, L., Passos, J.F., Robbins, P.D., Schmitt, C.A., Sedivy, J.M., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M., Demaria, M. Cellular Senescence: Defining a Path Forward. Cell. 2019. 79: 813-827. DOI:
  44. Barbosa, K., Li, S., Adams, P.D., Deshpande, A.J. The Role of TP53 in Acute Myeloid Leukemia: Challenges and Opportunities. Genes, Chromosomes & Cancer, 2019 Dec;58(12):875-888. doi: 10.1002/gcc.22796. Epub 2019 Sep 3.
  45. Blice-Baum, A.C., Guida, M.C., Hartley, P.S., Adams, P.D., Bodmer, R., Cammarato, A. As time flies by: Investigating cardiac aging in the short-lived Drosophila model. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1; 1865(7):1831-1844. doi: 10.1016/j.bbadis.2018.11.010. Epub 2018 Nov 27. Review. PubMed PMID: 30496794; PubMed Central PMCID: PMC6527462.
  46. Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck, S., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans, B.T., Horvath, S., Ideker, T., Issa, J-P.J., Kelsey, K.T., Marioni, R.E., Reik, W., Relton, C.L., Schalkwyk, L.C., Teschendorff, A.E., Wagner, W., Zhang, K., Rakyan, V. DNA methylation aging clocks: challenges and recommendations. Genome Biology. 2019. 20: 249
  47. Karl N Miller, Nirmalya Dasgupta, Tianhui Liu, Peter D Adams, Maria Grazia Vizioli. Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential. eLife 2021;10:e63728 doi: 10.7554/eLife.63728
  48. Shadel, G.S., Adams, P.D., Berggren, W.T., Diedrich, J.K., Diffenderfer, K.E., Gage, F.H., Hah, N., Hansen, M., Hetzer, M.W., Molina, A.J.A., Manor, U., Marek, K., O'Keefe, D.D., Pinto, A.F.M., Sacco, A., Sharpee, T.O., Shokriev, M.N., Zambetti, S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 Aug 9. doi: 10.1007/s11357-021-00426-x. Epub ahead of print. PMID: 34370163.
  49. Feng MW, Adams PD. A new mechanistic insight into fate decisions during yeast cell aging process. Mech Ageing Dev. 2021 Sep;198:111542. doi: 10.1016/j.mad.2021.111542. Epub 2021 Jul 15. PMID: 34273382; PMCID: PMC8407526.
  50. Miller, KN., Victorelli, SG., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, JF, Adams, PD. Cytoplasmic DNA: sources, sensing, and role in aging and disease. Cell 2021, 184, 5506-5526. Doi: 10.1016/j.cell.2021.09.034